Ablation of the Inflammatory Enzyme Myeloperoxidase Mitigates Features of Parkinson's Disease in Mice

Parkinson's disease (PD) is characterized by a loss of ventral midbrain dopaminergic neurons, which can be modeled by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Inflammatory oxidants have emerged as key contributors to PD- and MPTP-related neurodegeneration. Here, we sh...

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Foilsithe in:J Neurosci
Main Authors: Choi, Dong-Kug, Pennathur, Subramaniam, Perier, Celine, Tieu, Kim, Teismann, Peter, Wu, Du-Chu, Jackson-Lewis, Vernice, Vila, Miquel, Vonsattel, Jean-Paul, Heinecke, Jay W., Przedborski, Serge
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Neuroscience 2005
Ábhair:
Neurobiology of Disease
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725426/
https://ncbi.nlm.nih.gov/pubmed/16014720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0970-05.2005
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