Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) damages the nigrostriatal dopaminergic pathway as seen in Parkinson's disease (PD), a common neurodegenerative disorder with no effective protective treatment. Consistent with a role of glial cells in PD neurodegeneration, here we show that mi...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Wu, Du Chu, Jackson-Lewis, Vernice, Vila, Miquel, Tieu, Kim, Teismann, Peter, Vadseth, Caryn, Choi, Dong-Kug, Ischiropoulos, Harry, Przedborski, Serge
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2002
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ARTICLE
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758858/
https://ncbi.nlm.nih.gov/pubmed/11880505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-05-01763.2002
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