D-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease

Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of the nigrostriatal dopaminergic neurons accompanied by a deficit in mitochondrial respiration. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that causes dopaminergic neurodegeneration and a mitocho...

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Detalhes bibliográficos
Main Authors: Tieu, Kim, Perier, Celine, Caspersen, Casper, Teismann, Peter, Wu, Du-Chu, Yan, Shi-Du, Naini, Ali, Vila, Miquel, Jackson-Lewis, Vernice, Ramasamy, Ravichandran, Przedborski, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC193668/
https://ncbi.nlm.nih.gov/pubmed/12975474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318797
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