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Replication past a trans-4-Hydroxynonenal Minor-Groove Adduct by the Sequential Action of Human DNA Polymerases ι and κ

The X-ray crystal structure of human DNA polymerase ι (Polι) has shown that it differs from all known Pols in its dependence upon Hoogsteen base pairing for synthesizing DNA. Hoogsteen base pairing provides an elegant mechanism for synthesizing DNA opposite minor-groove adducts that present a severe...

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Bibliografische gegevens
Hoofdauteurs: Wolfle, William T., Johnson, Robert E., Minko, Irina G., Lloyd, R. Stephen, Prakash, Satya, Prakash, Louise
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2006
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317639/
https://ncbi.nlm.nih.gov/pubmed/16354708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.1.381-386.2006
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