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Human DNA Polymerase ι Promotes Replication through a Ring-Closed Minor-Groove Adduct That Adopts a syn Conformation in DNA
Acrolein, an α,β-unsaturated aldehyde, is generated in vivo as the end product of lipid peroxidation and from oxidation of polyamines. The reaction of acrolein with the N(2) group of guanine in DNA leads to the formation of a cyclic adduct, γ-hydroxy-1,N(2)-propano-2′-deoxyguanosine (γ-HOPdG). Previ...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1265759/ https://ncbi.nlm.nih.gov/pubmed/16166652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.19.8748-8754.2005 |
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