Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase, RNase H, and Integrase Activities by Hydroxytropolones

Human immunodeficiency virus type I reverse transcriptase (RT) possesses distinct DNA polymerase and RNase H sites, whereas integrase (IN) uses the same active site to perform 3′-end processing and strand transfer of the proviral DNA. These four enzymatic activities are essential for viral replicati...

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Bibliographic Details
Main Authors: Didierjean, Joël, Isel, Catherine, Querré, Flore, Mouscadet, Jean-François, Aubertin, Anne-Marie, Valnot, Jean-Yves, Piettre, Serge R., Marquet, Roland
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315922/
https://ncbi.nlm.nih.gov/pubmed/16304149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.12.4884-4894.2005
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