Inhibition of Foamy Virus Reverse Transcriptase by Human Immunodeficiency Virus Type 1 RNase H Inhibitors

RNase H plays an essential role in the replication of human immunodeficiency virus type 1 (HIV-1). Therefore, it is a promising target for drug development. However, the identification of HIV-1 RNase H inhibitors (RHIs) has been hampered by the open morphology of its active site, the limited number...

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Bibliographic Details
Main Authors: Corona, Angela, Schneider, Anna, Schweimer, Kristian, Rösch, Paul, Wöhrl, Birgitta M., Tramontano, Enzo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068541/
https://ncbi.nlm.nih.gov/pubmed/24798282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00056-14
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