AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase

BACKGROUND: The replication of simian foamy virus from macaques can be inhibited by the nucleoside reverse transcriptase inhibitor azidothymidine (AZT, zidovudine). Four substitutions in the protease-reverse transcriptase (PR-RT) protein (K211I, I224T, S345T, E350K) are necessary to obtain highly AZ...

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Bibliographic Details
Published in:Retrovirology
Main Authors: Schneider, Anna, Schweimer, Kristian, Rösch, Paul, Wöhrl, Birgitta M
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359774/
https://ncbi.nlm.nih.gov/pubmed/25808094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0147-7
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