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AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase
BACKGROUND: The replication of simian foamy virus from macaques can be inhibited by the nucleoside reverse transcriptase inhibitor azidothymidine (AZT, zidovudine). Four substitutions in the protease-reverse transcriptase (PR-RT) protein (K211I, I224T, S345T, E350K) are necessary to obtain highly AZ...
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| 出版年: | Retrovirology |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4359774/ https://ncbi.nlm.nih.gov/pubmed/25808094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0147-7 |
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