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AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP

Azidothymidine (AZT, zidovudine) is one of the few nucleoside inhibitors known to inhibit foamy virus replication. We have shown previously that up to four mutations in the reverse transcriptase gene of simian foamy virus from macaque (SFVmac) are necessary to confer high resistance against AZT. To...

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Main Authors: Hartl, Maximilian J., Kretzschmar, Benedikt, Frohn, Anne, Nowrouzi, Ali, Rethwilm, Axel, Wöhrl, Birgitta M.
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2241919/
https://ncbi.nlm.nih.gov/pubmed/18096624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1087
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