Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors

We analyzed a multi-drug resistant (MR) HIV-1 reverse transcriptase (RT), subcloned from a patient-derived subtype CRF02_AG, harboring 45 amino acid exchanges, amongst them four thymidine analog mutations (TAMs) relevant for high-level AZT (azidothymidine) resistance by AZTMP excision (M41L, D67N, T...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Schneider, Anna, Corona, Angela, Spöring, Imke, Jordan, Mareike, Buchholz, Bernd, Maccioni, Elias, Di Santo, Roberto, Bodem, Jochen, Tramontano, Enzo, Wöhrl, Birgitta M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797301/
https://ncbi.nlm.nih.gov/pubmed/26850643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw060
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