Insights into the structure and activity of prototype foamy virus RNase H

BACKGROUND: RNase H is an endonuclease that hydrolyzes the RNA strand in RNA/DNA hybrids. Retroviral reverse transcriptases harbor a C-terminal RNase H domain whose activity is essential for viral replication. The RNase H degrades the viral genomic RNA after the first DNA strand is synthesized. Here...

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Main Authors: Leo, Berit, Hartl, Maximilian J, Schweimer, Kristian, Mayr, Florian, Wöhrl, Birgitta M
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305377/
https://ncbi.nlm.nih.gov/pubmed/22325739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-14
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