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Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
Dicer is a multi-domain RNase III-related endonuclease responsible for processing double-stranded RNA (dsRNA) to small interfering RNAs (siRNAs) during a process of RNA interference (RNAi). It also catalyses excision of the regulatory microRNAs from their precursors. In this work, we describe the pu...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC131079/ https://ncbi.nlm.nih.gov/pubmed/12411505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf582 |
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