Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

Dicer is a multi-domain RNase III-related endonuclease responsible for processing double-stranded RNA (dsRNA) to small interfering RNAs (siRNAs) during a process of RNA interference (RNAi). It also catalyses excision of the regulatory microRNAs from their precursors. In this work, we describe the pu...

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Vydáno v:	EMBO J
Hlavní autoři:	Zhang, Haidi, Kolb, Fabrice A., Brondani, Vincent, Billy, Eric, Filipowicz, Witold
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 2002
Témata:	Articles
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC131079/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12411505/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf582
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