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Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

Dicer is a multi-domain RNase III-related endonuclease responsible for processing double-stranded RNA (dsRNA) to small interfering RNAs (siRNAs) during a process of RNA interference (RNAi). It also catalyses excision of the regulatory microRNAs from their precursors. In this work, we describe the pu...

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Udgivet i:EMBO J
Principais autores: Zhang, Haidi, Kolb, Fabrice A., Brondani, Vincent, Billy, Eric, Filipowicz, Witold
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC131079/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12411505/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf582
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