Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

Dicer is a multi-domain RNase III-related endonuclease responsible for processing double-stranded RNA (dsRNA) to small interfering RNAs (siRNAs) during a process of RNA interference (RNAi). It also catalyses excision of the regulatory microRNAs from their precursors. In this work, we describe the pu...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Haidi, Kolb, Fabrice A., Brondani, Vincent, Billy, Eric, Filipowicz, Witold
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2002
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC131079/
https://ncbi.nlm.nih.gov/pubmed/12411505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf582
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