Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1
Presenilins are part of a protease complex that is responsible for the intramembraneous cleavage of the amyloid precursor protein involved in Alzheimer’s disease and of Notch receptors. In Caenorhabditis elegans, mutations in the presenilin sel-12 result in a highly penetrant egg-laying defect. spr-...
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| Pubblicato in: | EMBO J |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC131058/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12411496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf561 |
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