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Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1
Presenilins are part of a protease complex that is responsible for the intramembraneous cleavage of the amyloid precursor protein involved in Alzheimer’s disease and of Notch receptors. In Caenorhabditis elegans, mutations in the presenilin sel-12 result in a highly penetrant egg-laying defect. spr-...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC131058/ https://ncbi.nlm.nih.gov/pubmed/12411496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf561 |
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