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Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1

Presenilins are part of a protease complex that is responsible for the intramembraneous cleavage of the amyloid precursor protein involved in Alzheimer’s disease and of Notch receptors. In Caenorhabditis elegans, mutations in the presenilin sel-12 result in a highly penetrant egg-laying defect. spr-...

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Bibliografische gegevens
Hoofdauteurs: Eimer, S., Lakowski, B., Donhauser, R., Baumeister, R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2002
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC131058/
https://ncbi.nlm.nih.gov/pubmed/12411496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf561
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