Reversing the defective induction of IL-10–secreting regulatory T cells in glucocorticoid-resistant asthma patients

We previously reported that human CD4(+) Tregs secrete high levels of IL-10 when stimulated in the presence of dexamethasone and calcitriol (vitamin D3). We now show that following stimulation by allergen, IL-10–secreting Tregs inhibit cytokine secretion by allergen-specific Th2 cells in an IL-10–de...

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Hauptverfasser: Xystrakis, Emmanuel, Kusumakar, Siddharth, Boswell, Sandra, Peek, Emma, Urry, Zoë, Richards, David F., Adikibi, Tonye, Pridgeon, Carol, Dallman, Margaret, Loke, Tuck-Kay, Robinson, Douglas S., Barrat, Franck J., O’Garra, Anne, Lavender, Paul, Lee, Tak H., Corrigan, Christopher, Hawrylowicz, Catherine M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1307558/
https://ncbi.nlm.nih.gov/pubmed/16341266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI21759
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