Ligation of TLR9 induced on human IL-10–secreting Tregs by 1α,25-dihydroxyvitamin D3 abrogates regulatory function

Signaling through the TLR family of molecular pattern recognition receptors has been implicated in the induction of innate and adaptive immune responses. A role for TLR signaling in the maintenance and/or regulation of Treg function has been proposed, however its functional relevance remains unclear...

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Detalhes bibliográficos
Main Authors: Urry, Zoë, Xystrakis, Emmanuel, Richards, David F., McDonald, Joanne, Sattar, Zahid, Cousins, David J., Corrigan, Christopher J., Hickman, Emma, Brown, Zarin, Hawrylowicz, Catherine M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631286/
https://ncbi.nlm.nih.gov/pubmed/19139565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32354
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