CD45 ligation expands Tregs by promoting interactions with DCs

Regulatory T cells (Tregs), which express CD4 and FOXP3, are critical for modulating the immune response and promoting immune tolerance. Consequently, methods to expand Tregs for therapeutic use are of great interest. While transfer of Tregs after massive ex vivo expansion can be achieved, in vivo e...

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Detalhes bibliográficos
Main Authors: Camirand, Geoffrey, Wang, Ying, Lu, Yuning, Wan, Yisong Y., Lin, Yan, Deng, Songyan, Guz, Galip, Perkins, David L., Finn, Patricia W., Farber, Donna L., Flavell, Richard A., Shlomchik, Warren D., Lakkis, Fadi G., Rudd, Christopher E., Rothstein, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191025/
https://ncbi.nlm.nih.gov/pubmed/25202978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74087
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