Normal Mode Analysis Suggests a Quaternary Twist Model for the Nicotinic Receptor Gating Mechanism

We present a three-dimensional model of the homopentameric α7 nicotinic acetylcholine receptor (nAChR), that includes the extracellular and membrane domains, developed by comparative modeling on the basis of: 1), the x-ray crystal structure of the snail acetylcholine binding protein, an homolog of t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Taly, Antoine, Delarue, Marc, Grutter, Thomas, Nilges, Michael, Le Novère, Nicolas, Corringer, Pierre-Jean, Changeux, Jean-Pierre
Format: Artigo
Sprache:Inglês
Veröffentlicht: Biophysical Society 2005
Schlagworte:
Channels, Receptors, and Electrical Signaling
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1305627/
https://ncbi.nlm.nih.gov/pubmed/15805177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.050229
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