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Energy Landscape Distortions and the Mechanical Unfolding of Proteins

Molecular simulations and an energy landscape analysis are used to examine the stretching of a model protein. A mapping of the energy landscape shows that stretching the protein causes energy minima and energy barriers to flatten out and disappear, and new energy minima to be created. The implicatio...

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Autore principale: Lacks, Daniel J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1305495/
https://ncbi.nlm.nih.gov/pubmed/15731385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.051953
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