Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling

Fibrinogen binding to integrin αIIbβ3 mediates platelet aggregation and requires agonist-induced “inside-out” signals that increase αIIbβ3 affinity. Agonist regulation of αIIbβ3 also takes place in megakaryocytes, the bone marrow cells from which platelets are derived. To facilitate mechanistic stud...

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Detaylı Bibliyografya
Asıl Yazarlar: Eto, Koji, Murphy, Ronan, Kerrigan, Steve W., Bertoni, Alessandra, Stuhlmann, Heidi, Nakano, Toru, Leavitt, Andrew D., Shattil, Sanford J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2002
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC130543/
https://ncbi.nlm.nih.gov/pubmed/12239348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202380099
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