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Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling
Fibrinogen binding to integrin αIIbβ3 mediates platelet aggregation and requires agonist-induced “inside-out” signals that increase αIIbβ3 affinity. Agonist regulation of αIIbβ3 also takes place in megakaryocytes, the bone marrow cells from which platelets are derived. To facilitate mechanistic stud...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC130543/ https://ncbi.nlm.nih.gov/pubmed/12239348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202380099 |
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