Structural Locus of the pH Gate in the Kir1.1 Inward Rectifier Channel

The closed-state crystal structure of prokaryotic inward rectifier, KirBac1.1, has implicated four inner helical phenylalanines near the cytoplasmic side as a possible locus of the channel gate. In the present study, we investigate whether this structural feature corresponds to the physiological pH...

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Main Authors: Sackin, Henry, Nanazashvili, Mikheil, Palmer, Lawrence G., Krambis, M., Walters, D. E.
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2005
Teme:
Channels, Receptors, and Electrical Signaling
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1305356/
https://ncbi.nlm.nih.gov/pubmed/15653740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.051474
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