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Concentration Effects of Volatile Anesthetics on the Properties of Model Membranes: A Coarse-Grain Approach

To gain insights into the molecular level mechanism of drug action at the membrane site, we have carried out extensive molecular dynamics simulations of a model membrane in the presence of a volatile anesthetic using a coarse-grain model. Six different anesthetic (halothane)/lipid (dimyristoylphosph...

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Detalhes bibliográficos
Main Authors: Pickholz, Mónica, Saiz, Leonor, Klein, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1305210/
https://ncbi.nlm.nih.gov/pubmed/15613628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.044354
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