Coarse-Grained Strategy for Modeling Protein Stability in Concentrated Solutions. II: Phase Behavior

We use highly efficient transition-matrix Monte Carlo simulations to determine equilibrium unfolding curves and fluid phase boundaries for solutions of coarse-grained globular proteins. The model we analyze derives the intrinsic stability of the native state and protein-protein interactions from bas...

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Autors principals: Shen, Vincent K., Cheung, Jason K., Errington, Jeffrey R., Truskett, Thomas M.
Format: Artigo
Idioma:Inglês
Publicat: Biophysical Society 2006
Matèries:
Biophysical Theory and Modeling
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1386775/
https://ncbi.nlm.nih.gov/pubmed/16387768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.076497
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