Binding Site in Eag Voltage Sensor Accommodates a Variety of Ions and is Accessible in Closed Channel

In ether-à-go-go K(+) channels, voltage-dependent activation is modulated by ion binding to a site located in an extracellular-facing crevice between transmembrane segments S2 and S3 in the voltage sensor. We find that acidic residues D278 in S2 and D327 in S3 are able to coordinate a variety of div...

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Bibliographic Details
Main Authors: Silverman, William R., Bannister, John P. A., Papazian, Diane M.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2004
Subjects:
Channels, Receptors, and Electrical Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304782/
https://ncbi.nlm.nih.gov/pubmed/15347589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.044602
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