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Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K(+) channel voltage sensor

In voltage-dependent ether-à-go-go (eag) K(+) channels, the process of activation is modulated by Mg(2+) and other divalent cations, which bind to a site in the voltage sensor and slow channel opening. Previous analysis of eag ionic and gating currents indicated that Mg(2+) has a much larger effect...

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Bibliografski detalji
Glavni autori: Bannister, John P. A., Chanda, Baron, Bezanilla, Francisco, Papazian, Diane M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317915/
https://ncbi.nlm.nih.gov/pubmed/16339906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505766102
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