Lipoelectric Modification of Ion Channel Voltage Gating by Polyunsaturated Fatty Acids

Polyunsaturated fatty acids (PUFAs) have beneficial effects on epileptic seizures and cardiac arrhythmia. We report that ω-3 and ω-6 all-cis-PUFAs affected the voltage dependence of the Shaker K channel by shifting the conductance versus voltage and the gating charge versus voltage curves in negativ...

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Bibliografiske detaljer
Main Authors: Börjesson, Sara I., Hammarström, Sven, Elinder, Fredrik
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2008
Fag:
Channels, Receptors, and Electrical Signaling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517024/
https://ncbi.nlm.nih.gov/pubmed/18502799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.130757
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