Novel Interactions Identified between μ-Conotoxin and the Na(+) Channel Domain I P-loop: Implications for Toxin-Pore Binding Geometry

μ-Conotoxins (μ-CTX) are peptides that inhibit Na(+) flux by blocking the Na(+) channel pore. Toxin residue arginine 13 is critical for both high affinity binding and for complete block of the single channel current, prompting the simple conventional view that residue 13 (R13) leads toxin docking by...

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Detaylı Bibliyografya
Asıl Yazarlar: Xue, Tian, Ennis, Irene L., Sato, Kazuki, French, Robert J., Li, Ronald A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Biophysical Society 2003
Konular:
Channels, Receptors, and Transporters
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303455/
https://ncbi.nlm.nih.gov/pubmed/14507694
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