Trans-Channel Interactions in Batrachotoxin-Modified Rat Skeletal Muscle Sodium Channels: Kinetic Analysis of Mutual Inhibition between μ-Conotoxin GIIIA Derivatives and Amine Blockers

R13X derivatives of μ-conotoxin GIIIA bind externally to single sodium channels and block current incompletely with mean “blocked” durations of several seconds. We studied interactions between two classes of blockers (μ-conotoxins and amines) by steady state, kinetic analysis of block of BTX-modifie...

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Detalhes bibliográficos
Main Authors: Ma, Quanli, Pavlov, Evgeny, Britvina, Tatiana, Zamponi, Gerald W., French, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2008
Assuntos:
Channels, Receptors, and Electrical Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567937/
https://ncbi.nlm.nih.gov/pubmed/18658223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.138271
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