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Docking of μ-Conotoxin GIIIA in the Sodium Channel Outer Vestibule

μ-Conotoxin GIIIA (μ-CTX) is a high-affinity ligand for the outer vestibule of selected isoforms of the voltage-gated Na(+) channel. The detailed bases for the toxin’s high affinity binding and isoform selectivity are unclear. The outer vestibule is lined by four pore-forming (P) loops, each with an...

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Main Authors: Choudhary, Gaurav, Aliste, Marcela P., Tieleman, D. Peter, French, Robert J., Dudley, Samuel C.
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3212855/
https://ncbi.nlm.nih.gov/pubmed/18690041
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