Novel Interactions Identified between μ-Conotoxin and the Na(+) Channel Domain I P-loop: Implications for Toxin-Pore Binding Geometry

μ-Conotoxins (μ-CTX) are peptides that inhibit Na(+) flux by blocking the Na(+) channel pore. Toxin residue arginine 13 is critical for both high affinity binding and for complete block of the single channel current, prompting the simple conventional view that residue 13 (R13) leads toxin docking by...

詳細記述

保存先:
書誌詳細
主要な著者: Xue, Tian, Ennis, Irene L., Sato, Kazuki, French, Robert J., Li, Ronald A.
フォーマット: Artigo
言語:Inglês
出版事項: Biophysical Society 2003
主題:
Channels, Receptors, and Transporters
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303455/
https://ncbi.nlm.nih.gov/pubmed/14507694
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