Novel Interactions Identified between μ-Conotoxin and the Na(+) Channel Domain I P-loop: Implications for Toxin-Pore Binding Geometry

μ-Conotoxins (μ-CTX) are peptides that inhibit Na(+) flux by blocking the Na(+) channel pore. Toxin residue arginine 13 is critical for both high affinity binding and for complete block of the single channel current, prompting the simple conventional view that residue 13 (R13) leads toxin docking by...

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Autores principales: Xue, Tian, Ennis, Irene L., Sato, Kazuki, French, Robert J., Li, Ronald A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Biophysical Society 2003
Materias:
Channels, Receptors, and Transporters
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303455/
https://ncbi.nlm.nih.gov/pubmed/14507694
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