Significance of ligand tails for interaction with the minor groove of B-DNA.

Minor groove binding ligands are of great interest due to their extraordinary importance as transcription controlling drugs. We performed three molecular dynamics simulations of the unbound d(CGCGAATTCGCG)(2) dodecamer and its complexes with Hoechst33258 and Netropsin. The structural behavior of the...

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Bibliographic Details
Main Authors: Wellenzohn, B, Flader, W, Winger, R H, Hallbrucker, A, Mayer, E, Liedl, K R
Format: Artigo
Language:Inglês
Published: 2001
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301637/
https://ncbi.nlm.nih.gov/pubmed/11509372
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