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A role for water molecules in DNA-ligand minor groove recognition

Targeting the minor groove of DNA through binding to a small molecule has long been considered an important molecular-recognition strategy in biology. A wide range of synthetic heterocyclic molecules bind non-covalently in the minor groove of the double helix and are also effective against a number...

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Detalhes bibliográficos
Main Authors: Nguyen, Binh, Neidle, Stephen, Wilson, W. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668807/
https://ncbi.nlm.nih.gov/pubmed/18798655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ar800016q
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