Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA(2) phosphorylation and translocation

BACKGROUND: The 85-kDa cytosolic phospholipase A(2) (cPLA(2)) mediates arachidonic acid (AA) release in MDCK cells. Although calcium and mitogen-activated protein kinases regulate cPLA(2), the correlation of cPLA(2) translocation and phosphorylation with MAPK activation and AA release is unclear. RE...

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Bibliographische Detailangaben
Hauptverfasser: Evans, John H, Fergus, Daniel J, Leslie, Christina C
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2002
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC130032/
https://ncbi.nlm.nih.gov/pubmed/12370087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-3-30
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