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Off-target effect of the cPLA(2)α inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum
Cytosolic phospholipase A(2)α (cPLA(2)α) mediates agonist-induced release of arachidonic acid from membrane phospholipid for production of eicosanoids. The activation of cPLA(2)α involves increases in intracellular calcium, which binds to the C2 domain and promotes cPLA(2)α translocation from the cy...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5063313/ https://ncbi.nlm.nih.gov/pubmed/27620490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.09.033 |
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