ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation

Upon activation, ERKs translocate from the cytoplasm to the nucleus. This process is required for the induction of many cellular responses, yet the molecular mechanisms that regulate ERK nuclear translocation are not fully understood. We have used a mouse embryo fibroblast ERK1-knock-out cell line e...

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Bibliografiske detaljer
Main Authors: Lidke, Diane S., Huang, Fang, Post, Janine N., Rieger, Bernd, Wilsbacher, Julie, Thomas, James L., Pouysségur, Jacques, Jovin, Thomas M., Lenormand, Philippe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823437/
https://ncbi.nlm.nih.gov/pubmed/19920141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064972
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