Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation.

The Helicobacter pylori VacA toxin plays a major role in the gastric pathologies associated with this bacterium. When added to cultured cells, VacA induces vacuolation, an effect potentiated by preexposure of the toxin to low pH. Its mechanism of action is unknown. We report here that VacA forms ani...

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Autores principales: Tombola, F, Carlesso, C, Szabò, I, de Bernard, M, Reyrat, J M, Telford, J L, Rappuoli, R, Montecucco, C, Papini, E, Zoratti, M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1999
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1300118/
https://ncbi.nlm.nih.gov/pubmed/10049322
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