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Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity.

The vacuolating toxin VacA, a major determinant of Helicobacter pylori-associated gastric diseases, forms anion-selective channels in artificial planar lipid bilayers. Here we show that VacA increases the anion permeability of the HeLa cell plasma membrane and determines membrane depolarization. Ele...

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Detalhes bibliográficos
Main Authors: Szabò, I, Brutsche, S, Tombola, F, Moschioni, M, Satin, B, Telford, J L, Rappuoli, R, Montecucco, C, Papini, E, Zoratti, M
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171620/
https://ncbi.nlm.nih.gov/pubmed/10523296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.20.5517
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