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The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia

Urease and the cytotoxin VacA are two major virulence factors of the human pathogen Helicobacter pylori, which is responsible for severe gastroduodenal diseases. Diffusion of urea, the substrate of urease, into the stomach is critically required for the survival of infecting H. pylori. We now show t...

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Detalhes bibliográficos
Main Authors: Tombola, Francesco, Morbiato, Laura, Del Giudice, Giuseppe, Rappuoli, Rino, Zoratti, Mario, Papini, Emanuele
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC200932/
https://ncbi.nlm.nih.gov/pubmed/11560962
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