The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia

Urease and the cytotoxin VacA are two major virulence factors of the human pathogen Helicobacter pylori, which is responsible for severe gastroduodenal diseases. Diffusion of urea, the substrate of urease, into the stomach is critically required for the survival of infecting H. pylori. We now show t...

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Pubblicato in:	J Clin Invest
Autori principali:	Tombola, Francesco, Morbiato, Laura, Del Giudice, Giuseppe, Rappuoli, Rino, Zoratti, Mario, Papini, Emanuele
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC200932/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11560962/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI13045
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