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The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia

Urease and the cytotoxin VacA are two major virulence factors of the human pathogen Helicobacter pylori, which is responsible for severe gastroduodenal diseases. Diffusion of urea, the substrate of urease, into the stomach is critically required for the survival of infecting H. pylori. We now show t...

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Udgivet i:J Clin Invest
Principais autores: Tombola, Francesco, Morbiato, Laura, Del Giudice, Giuseppe, Rappuoli, Rino, Zoratti, Mario, Papini, Emanuele
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC200932/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11560962/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI13045
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