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Association of MHC and rheumatoid arthritis: Association of RA with HLA-DR4 - the role of repertoire selection

Most patients with rheumatoid arthritis (RA) express HLA-DR4, HLA-DR1 or HLA-DR10. These alleles share a common amino acid motif in their third hypervariable regions: the shared epitope. In normals and patients with RA, HLA-DR genes exert a major influence on the CD4 αβ T-cell repertoire, as shown b...

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Bibliografische gegevens
Gepubliceerd in:Arthritis Res
Hoofdauteur: Roudier, Jean
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2000
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC130006/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11094433/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/ar91
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