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Association of MHC and rheumatoid arthritis: Association of RA with HLA-DR4 - the role of repertoire selection
Most patients with rheumatoid arthritis (RA) express HLA-DR4, HLA-DR1 or HLA-DR10. These alleles share a common amino acid motif in their third hypervariable regions: the shared epitope. In normals and patients with RA, HLA-DR genes exert a major influence on the CD4 αβ T-cell repertoire, as shown b...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2000
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC130006/ https://ncbi.nlm.nih.gov/pubmed/11094433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar91 |
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