Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice

Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II collagen (CII) is a candidate, and the DR4- and DR1-restricted immunodominant T cell epitope in this protein corresponds to amino acids 261–273 (CII...

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Autori principali: Andersson, Ellen Christina, Hansen, Bjarke Endel, Jacobsen, Helle, Madsen, Lars S., Andersen, Claus B., Engberg, Jan, Rothbard, Jonathan B., McDevitt, Grete Sønderstrup, Malmström, Vivianne, Holmdahl, Rikard, Svejgaard, Arne, Fugger, Lars
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1998
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC22687/
https://ncbi.nlm.nih.gov/pubmed/9636191
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