Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior

By using single-molecule measurements, we demonstrate that the elongation kinetics of individual Escherichia coli RNA polymerase molecules are remarkably homogeneous. We find no evidence of distinct elongation states among RNA polymerases. Instead, the observed heterogeneity in transcription rates r...

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Päätekijät: Adelman, Karen, La Porta, Arthur, Santangelo, Thomas J., Lis, John T., Roberts, Jeffrey W., Wang, Michelle D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The National Academy of Sciences 2002
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC129709/
https://ncbi.nlm.nih.gov/pubmed/12370445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212358999
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